1978 Week 4
| Sep 24, 1978 | ||
| Baltimore Colts | 17 | Final |
| Buffalo Bills | 24 | |
| PassYds | Ferguson-BUF | 154 |
| RushYds | Miller-BUF | 97 |
| RecYds | Lewis-BUF | 62 |
| Sep 24, 1978 | ||
| New Orleans Saints | 20 | Final |
| Cincinnati Bengals | 18 | |
| PassYds | Manning-NOR | 208 |
| RushYds | Johnson-CIN | 98 |
| RecYds | 2 tied | 81 |
| Sep 24, 1978 | ||
| Los Angeles Rams | 10 | Final |
| Houston Oilers | 6 | |
| PassYds | Haden-RAM | 220 |
| RushYds | Cappelletti-RAM | 78 |
| RecYds | Nelson-RAM | 98 |
| Sep 24, 1978 | ||
| Miami Dolphins | 3 | Final |
| Philadelphia Eagles | 17 | |
| PassYds | Jaworski-PHI | 128 |
| RushYds | Montgomery-PHI | 111 |
| RecYds | Carmichael-PHI | 50 |
| Sep 24, 1978 | ||
| Cleveland Browns | 9 | Final |
| Pittsburgh Steelers | 15 | OT |
| PassYds | Bradshaw-PIT | 208 |
| RushYds | Harris-PIT | 84 |
| RecYds | Swann-PIT | 83 |
| Sep 24, 1978 | ||
| New York Jets | 3 | Final |
| Washington Redskins | 23 | |
| PassYds | Theismann-WAS | 209 |
| RushYds | Riggins-WAS | 114 |
| RecYds | Walker-NYJ | 62 |
| Sep 24, 1978 | ||
| Denver Broncos | 23 | Final |
| Kansas City Chiefs | 17 | OT |
| PassYds | Morton-DEN | 138 |
| RushYds | Canada-DEN | 94 |
| RecYds | Odoms-DEN | 60 |
| Sep 24, 1978 | ||
| St. Louis Cardinals | 12 | Final |
| Dallas Cowboys | 21 | |
| PassYds | Hart-STL | 204 |
| RushYds | Dorsett-DAL | 154 |
| RecYds | Gray-STL | 107 |
| Sep 24, 1978 | ||
| San Francisco 49ers | 10 | Final |
| New York Giants | 27 | |
| PassYds | Pisarcik-NYG | 154 |
| RushYds | Hammond-NYG | 93 |
| RecYds | Dixon-NYG | 56 |
| Sep 24, 1978 | ||
| Green Bay Packers | 24 | Final |
| San Diego Chargers | 3 | |
| PassYds | Harris-SDG | 111 |
| RushYds | Middleton-GNB | 66 |
| RecYds | Joiner-SDG | 53 |
| Sep 24, 1978 | ||
| Detroit Lions | 16 | Final |
| Seattle Seahawks | 28 | |
| PassYds | Zorn-SEA | 189 |
| RushYds | Bussey-DET | 120 |
| RecYds | Largent-SEA | 85 |
| Sep 24, 1978 | ||
| Atlanta Falcons | 9 | Final |
| Tampa Bay Buccaneers | 14 | |
| PassYds | Bartkowski-ATL | 81 |
| RushYds | Stanback-ATL | 112 |
| RecYds | Hagins-TAM | 45 |
| Sep 24, 1978 | ||
| New England Patriots | 21 | Final |
| Oakland Raiders | 14 | |
| PassYds | Grogan-NWE | 219 |
| RushYds | Grogan-NWE | 65 |
| RecYds | Francis-NWE | 126 |
| Sep 25, 1978 | ||
| Minnesota Vikings | 24 | Final |
| Chicago Bears | 20 | |
| PassYds | Avellini-CHI | 207 |
| RushYds | Young-MIN | 81 |
| RecYds | White-MIN | 82 |
1978 Week Summaries