1980 Week 2
| Sep 11, 1980 | ||
| Los Angeles Rams | 9 | Final |
| Tampa Bay Buccaneers | 10 | |
| PassYds | Ferragamo-RAM | 191 |
| RushYds | Thomas-RAM | 64 |
| RecYds | Waddy-RAM | 88 |
| Sep 14, 1980 | ||
| New York Jets | 10 | Final |
| Buffalo Bills | 20 | |
| PassYds | Ferguson-BUF | 207 |
| RushYds | Gaines-NYJ | 94 |
| RecYds | Gaines-NYJ | 91 |
| Sep 14, 1980 | ||
| Philadelphia Eagles | 42 | Final |
| Minnesota Vikings | 7 | |
| PassYds | Jaworski-PHI | 234 |
| RushYds | Montgomery-PHI | 169 |
| RecYds | Carmichael-PHI | 95 |
| Sep 14, 1980 | ||
| Atlanta Falcons | 37 | Final |
| New England Patriots | 21 | |
| PassYds | Bartkowski-ATL | 244 |
| RushYds | Andrews-ATL | 124 |
| RecYds | Miller-ATL | 117 |
| Sep 14, 1980 | ||
| New Orleans Saints | 3 | Final |
| Chicago Bears | 22 | |
| PassYds | Manning-NOR | 168 |
| RushYds | Payton-CHI | 183 |
| RecYds | Harris-NOR | 75 |
| Sep 14, 1980 | ||
| Pittsburgh Steelers | 20 | Final |
| Baltimore Colts | 17 | |
| PassYds | Bradshaw-PIT | 282 |
| RushYds | Thornton-PIT | 54 |
| RecYds | Carr-BAL | 108 |
| Sep 14, 1980 | ||
| Detroit Lions | 29 | Final |
| Green Bay Packers | 7 | |
| PassYds | Danielson-DET | 246 |
| RushYds | Sims-DET | 134 |
| RecYds | Sims-DET | 94 |
| Sep 14, 1980 | ||
| Seattle Seahawks | 17 | Final |
| Kansas City Chiefs | 16 | |
| PassYds | Zorn-SEA | 194 |
| RushYds | 2 tied | 32 |
| RecYds | McCullum-SEA | 96 |
| Sep 14, 1980 | ||
| Dallas Cowboys | 20 | Final |
| Denver Broncos | 41 | |
| PassYds | White-DAL | 292 |
| RushYds | Dorsett-DAL | 62 |
| RecYds | Hill-DAL | 117 |
| Sep 14, 1980 | ||
| Cincinnati Bengals | 16 | Final |
| Miami Dolphins | 17 | |
| PassYds | Strock-MIA | 145 |
| RushYds | Williams-MIA | 65 |
| RecYds | Harris-MIA | 62 |
| Sep 14, 1980 | ||
| Washington Redskins | 23 | Final |
| New York Giants | 21 | |
| PassYds | Simms-NYG | 174 |
| RushYds | Claitt-WAS | 77 |
| RecYds | Gray-NYG | 63 |
| Sep 14, 1980 | ||
| Oakland Raiders | 24 | Final |
| San Diego Chargers | 30 | OT |
| PassYds | Fouts-SDG | 387 |
| RushYds | King-OAK | 70 |
| RecYds | Winslow-SDG | 132 |
| Sep 14, 1980 | ||
| St. Louis Cardinals | 21 | Final |
| San Francisco 49ers | 24 | OT |
| PassYds | DeBerg-SFO | 266 |
| RushYds | Hofer-SFO | 89 |
| RecYds | Hofer-SFO | 135 |
| Sep 15, 1980 | ||
| Houston Oilers | 16 | Final |
| Cleveland Browns | 7 | |
| PassYds | Stabler-HOU | 187 |
| RushYds | Campbell-HOU | 106 |
| RecYds | Barber-HOU | 47 |
1980 Week Summaries