Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Nick Mullens | 23 | Rook | 8 | 176 for 274, 2,277 yards, 13 td, 10 int, & 18 rushes for -16 yards and 0 td | |
| RB | Matt Breida | 23 | 1 | 13 | 153 rushes for 814 yards, 3 td, & 27 catches for 261 yards and 2 td | |
| FB | Kyle Juszczyk* | 27 | 5 | 14 | 8 rushes for 30 yards, 0 td, & 30 catches for 324 yards and 1 td | |
| WR | Pierre Garcon | 32 | 10 | 8 | 24 catches for 286 yards, 1 td | |
| WR | Marquise Goodwin | 28 | 5 | 8 | 23 catches for 395 yards, 4 td, & 4 rushes for 9 yards and 0 td | |
| TE | George Kittle* | 25 | 1 | 16 | 88 catches for 1,377 yards, 5 td, & 1 rush for 10 yards and 0 td | |
| LT | Joe Staley | 34 | 11 | 16 | ||
| LG | Laken Tomlinson | 26 | 3 | 16 | 1 fumble recovered | |
| C | Weston Richburg | 27 | 4 | 15 | ||
| RG | Mike McGlinchey | 23 | Rook | 16 | ||
| RG | Michael Person | 30 | 5 | 16 | 1 fumble recovered | |
| Defensive Starters | ||||||
| LDE | Solomon Thomas | 23 | 1 | 13 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LDT | Earl Mitchell | 31 | 8 | 12 | ||
| RDT | DeForest Buckner* | 24 | 2 | 16 | 12.0 sacks, 0 interceptions, 1 fumble recovered | |
| RDE | Arik Armstead | 25 | 3 | 16 | 3.0 sacks, 0 interceptions, 0 fumbles recovered | |
| MLB | Fred Warner | 22 | Rook | 16 | 0.0 sacks, 0 interceptions, 1 fumble recovered | |
| RLB | Reuben Foster | 24 | 1 | 6 | ||
| LCB | Richard Sherman | 30 | 7 | 14 | 1.0 sacks, 0 interceptions, 1 fumble recovered | |
| RCB | Ahkello Witherspoon | 23 | 1 | 12 | 0.0 sacks, 0 interceptions, 1 fumble recovered | |
| SS | Jaquiski Tartt | 26 | 3 | 8 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
| FS | Adrian Colbert | 25 | 1 | 6 | ||
| DB | K'Waun Williams | 27 | 4 | 11 |
Roster