Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Brian Hoyer | 32 | 8 | 6 | 119 for 205, 1,245 yards, 4 td, 4 int, & 5 rushes for 7 yards and 1 td | |
| RB | Carlos Hyde | 27 | 3 | 16 | 240 rushes for 938 yards, 8 td, & 59 catches for 350 yards and 0 td | |
| FB | Kyle Juszczyk* | 26 | 4 | 10 | 7 rushes for 31 yards, 0 td, & 33 catches for 315 yards and 1 td | |
| WR | Pierre Garcon | 31 | 9 | 8 | 40 catches for 500 yards, 0 td | |
| WR | Marquise Goodwin | 27 | 4 | 16 | 56 catches for 962 yards, 2 td, & 4 rushes for 44 yards and 0 td | |
| TE | Garrett Celek | 29 | 5 | 13 | 21 catches for 336 yards, 4 td | |
| LT | Joe Staley* | 33 | 10 | 15 | 1 fumble recovered | |
| LG | Laken Tomlinson | 25 | 2 | 15 | ||
| C | Daniel Kilgore | 30 | 6 | 16 | ||
| RG | Brandon Fusco | 29 | 6 | 16 | ||
| RT | Trent Brown | 24 | 2 | 10 | ||
| Defensive Starters | ||||||
| LDE | Arik Armstead | 24 | 2 | 6 | 1.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LDT | Earl Mitchell | 30 | 7 | 16 | 1.0 sacks, 0 interceptions, 1 fumble recovered | |
| RDT | DeForest Buckner | 23 | 1 | 16 | 3.0 sacks, 0 interceptions, 0 fumbles recovered | |
| RDE | Solomon Thomas | 22 | Rook | 12 | 3.0 sacks, 0 interceptions, 1 fumble recovered | |
| LLB | Eli Harold | 23 | 2 | 10 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
| MLB | Reuben Foster | 23 | Rook | 10 | ||
| RLB | Brock Coyle | 27 | 3 | 10 | 0.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LCB | Ahkello Witherspoon | 22 | Rook | 9 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
| RCB | Dontae Johnson | 26 | 3 | 16 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
| SS | Eric Reid | 26 | 4 | 12 | 0.0 sacks, 2 interceptions, 1 fumble recovered | |
| FS | Jimmie Ward | 26 | 3 | 6 | 0.0 sacks, 0 interceptions, 1 fumble recovered |
Roster