Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Colin Kaepernick | 26 | 2 | 16 | 243 for 416, 3,197 yards, 21 td, 8 int, & 92 rushes for 524 yards and 4 td | |
| RB | Frank Gore* | 30 | 8 | 16 | 276 rushes for 1,128 yards, 9 td, & 16 catches for 141 yards and 0 td | |
| RB | Bruce Miller | 26 | 2 | 13 | 7 rushes for 13 yards, 0 td, & 25 catches for 243 yards and 0 td | |
| WR | Anquan Boldin | 33 | 10 | 16 | 85 catches for 1,179 yards, 7 td, & 2 rushes for 11 yards and 0 td | |
| WR | Michael Crabtree | 26 | 4 | 5 | 19 catches for 284 yards, 1 td | |
| TE | Vernon Davis* | 29 | 7 | 15 | 52 catches for 850 yards, 13 td | |
| LT | Joe Staley* | 29 | 6 | 16 | ||
| LG | Mike Iupati* | 26 | 3 | 12 | ||
| C | Jonathan Goodwin | 35 | 11 | 16 | ||
| RG | Alex Boone | 26 | 3 | 16 | ||
| RT | Anthony Davis | 24 | 3 | 16 | ||
| Defensive Starters | ||||||
| LDE | Ray McDonald | 29 | 6 | 14 | 3.5 sacks, 0 interceptions, 0 fumbles recovered | |
| NT | Glenn Dorsey | 28 | 5 | 13 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
| RDE | Justin Smith* | 34 | 12 | 16 | 6.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LOLB | Ahmad Brooks* | 29 | 7 | 16 | 8.5 sacks, 1 interception, 1 fumble recovered | |
| LILB | NaVorro Bowman*+ | 25 | 3 | 16 | 5.0 sacks, 2 interceptions, 2 fumbles recovered | |
| RILB | Patrick Willis* | 28 | 6 | 14 | 3.0 sacks, 0 interceptions, 0 fumbles recovered | |
| ROLB | Aldon Smith | 24 | 2 | 8 | 8.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LCB | Carlos Rogers | 32 | 8 | 16 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
| RCB | Tarell Brown | 28 | 6 | 10 | 0.0 sacks, 0 interceptions, 2 fumbles recovered | |
| SS | Donte Whitner | 28 | 7 | 16 | 0.0 sacks, 2 interceptions, 1 fumble recovered | |
| FS | Eric Reid* | 22 | Rook | 16 | 0.0 sacks, 4 interceptions, 2 fumbles recovered |
Roster