| Offensive Starters | | | | | |
QB | Alex Smith | 28 | 7 | 9 | 153 for 218, 1,737 yards, 13 td, 5 int, & 31 rushes for 132 yards and 0 td | |
RB | Frank Gore* | 29 | 7 | 16 | 258 rushes for 1,214 yards, 8 td, & 28 catches for 234 yards and 1 td | |
FB | Bruce Miller | 25 | 1 | 13 | 5 rushes for 18 yards, 0 td, & 12 catches for 84 yards and 0 td | |
WR | Michael Crabtree | 25 | 3 | 16 | 85 catches for 1,105 yards, 9 td, & 1 rush for 8 yards and 0 td | |
WR | Mario Manningham | 26 | 4 | 10 | 42 catches for 449 yards, 1 td, & 3 rushes for 64 yards and 0 td | |
TE | Vernon Davis | 28 | 6 | 16 | 41 catches for 548 yards, 5 td | |
LT | Joe Staley* | 28 | 5 | 16 | 1 fumble recovered | |
LG | Mike Iupati*+ | 25 | 2 | 16 | | |
C | Jonathan Goodwin | 34 | 10 | 16 | | |
RG | Alex Boone | 25 | 2 | 16 | | |
RT | Anthony Davis | 23 | 2 | 16 | 1 fumble recovered | |
| Defensive Starters | | | | | |
LDE | Ray McDonald | 28 | 5 | 16 | 2.5 sacks, 0 interceptions, 0 fumbles recovered | |
NT | Isaac Sopoaga | 31 | 7 | 9 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
RDE | Justin Smith* | 33 | 11 | 14 | 3.0 sacks, 0 interceptions, 1 fumble recovered | |
LOLB | Ahmad Brooks | 28 | 6 | 16 | 6.5 sacks, 1 interception, 0 fumbles recovered | |
LILB | NaVorro Bowman*+ | 24 | 2 | 16 | 2.0 sacks, 1 interception, 0 fumbles recovered | |
RILB | Patrick Willis*+ | 27 | 5 | 16 | 0.5 sacks, 2 interceptions, 1 fumble recovered | |
ROLB | Aldon Smith*+ | 23 | 1 | 16 | 19.5 sacks, 1 interception, 0 fumbles recovered | |
LCB | Carlos Rogers | 31 | 7 | 16 | 1.0 sacks, 1 interception, 3 fumbles recovered | |
RCB | Tarell Brown | 27 | 5 | 16 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
SS | Donte Whitner* | 27 | 6 | 16 | 0.0 sacks, 1 interception, 1 fumble recovered | |
FS | Dashon Goldson*+ | 28 | 5 | 16 | 0.0 sacks, 3 interceptions, 2 fumbles recovered | |
Roster