Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Alex Smith | 25 | 4 | 10 | 225 for 372, 2,350 yards, 18 td, 12 int, & 24 rushes for 51 yards and 0 td | |
| RB | Frank Gore* | 26 | 4 | 14 | 229 rushes for 1,120 yards, 10 td, & 52 catches for 406 yards and 3 td | |
| FB | Delanie Walker | 25 | 3 | 8 | 3 rushes for 34 yards, 0 td, & 21 catches for 233 yards and 0 td | |
| WR | Michael Crabtree | 22 | Rook | 11 | 48 catches for 625 yards, 2 td | |
| WR | Josh Morgan | 24 | 1 | 15 | 52 catches for 527 yards, 3 td, & 5 rushes for 61 yards and 0 td | |
| TE | Vernon Davis* | 25 | 3 | 16 | 78 catches for 965 yards, 13 td | |
| LT | Joe Staley | 25 | 2 | 9 | 2 fumbles recovered | |
| LG | David Baas | 28 | 4 | 16 | ||
| C | Eric Heitmann | 29 | 7 | 16 | ||
| RG | Chilo Rachal | 23 | 1 | 15 | ||
| RT | Adam Snyder | 27 | 4 | 16 | ||
| Defensive Starters | ||||||
| LDE | Isaac Sopoaga | 28 | 4 | 16 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
| NT | Aubrayo Franklin | 29 | 6 | 16 | 2.0 sacks, 1 interception, 0 fumbles recovered | |
| RDE | Justin Smith* | 30 | 8 | 16 | 6.0 sacks, 0 interceptions, 2 fumbles recovered | |
| LOLB | Manny Lawson | 25 | 3 | 16 | 6.5 sacks, 0 interceptions, 1 fumble recovered | |
| LILB | Takeo Spikes | 33 | 11 | 15 | 4.0 sacks, 0 interceptions, 1 fumble recovered | |
| RILB | Patrick Willis*+ | 24 | 2 | 16 | 4.0 sacks, 3 interceptions, 0 fumbles recovered | |
| ROLB | Parys Haralson | 25 | 3 | 16 | 5.0 sacks, 0 interceptions, 1 fumble recovered | |
| LCB | Nate Clements | 30 | 8 | 6 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
| RCB | Shawntae Spencer | 27 | 5 | 16 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
| SS | Michael Lewis | 29 | 7 | 15 | 1.0 sacks, 1 interception, 1 fumble recovered | |
| FS | Dashon Goldson | 25 | 2 | 16 | 2.0 sacks, 4 interceptions, 1 fumble recovered |
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