Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Alex Smith | 22 | 1 | 16 | 257 for 442, 2,890 yards, 16 td, 16 int, & 44 rushes for 147 yards and 2 td | |
| RB | Frank Gore* | 23 | 1 | 16 | 312 rushes for 1,695 yards, 8 td, & 61 catches for 485 yards and 1 td | |
| WR | Arnaz Battle | 26 | 3 | 15 | 59 catches for 686 yards, 3 td, & 5 rushes for 25 yards and 0 td | |
| WR | Antonio Bryant | 25 | 4 | 13 | 40 catches for 733 yards, 3 td | |
| TE | Vernon Davis | 22 | Rook | 8 | 20 catches for 265 yards, 3 td, & 2 rushes for 5 yards and 0 td | |
| TE | Eric Johnson | 27 | 5 | 9 | 34 catches for 292 yards, 2 td | |
| LT | Jonas Jennings | 29 | 5 | 13 | ||
| LG | Larry Allen* | 35 | 12 | 11 | ||
| C | Eric Heitmann | 26 | 4 | 14 | ||
| RG | Justin Smiley | 25 | 2 | 16 | 1 fumble recovered | |
| RT | Kwame Harris | 24 | 3 | 16 | 1 fumble recovered | |
| Defensive Starters | ||||||
| LDE | Bryant Young | 34 | 12 | 16 | 5.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LDT | Ronald Fields | 25 | 1 | 9 | ||
| RDT | Marques Douglas | 29 | 6 | 16 | 3.0 sacks, 0 interceptions, 1 fumble recovered | |
| RDE | Melvin Oliver | 23 | Rook | 14 | 1.0 sacks, 0 interceptions, 1 fumble recovered | |
| LLB | Manny Lawson | 22 | Rook | 12 | 2.5 sacks, 1 interception, 2 fumbles recovered | |
| MLB | Derek Smith | 31 | 9 | 12 | ||
| RLB | Brandon Moore | 27 | 4 | 11 | 6.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LCB | Shawntae Spencer | 24 | 2 | 13 | 2.0 sacks, 1 interception, 2 fumbles recovered | |
| RCB | Walt Harris* | 32 | 10 | 15 | 1.0 sacks, 8 interceptions, 2 fumbles recovered | |
| SS | Mark Roman | 29 | 6 | 11 | 1.0 sacks, 1 interception, 1 fumble recovered | |
| FS | Keith Lewis | 25 | 2 | 9 | 1.0 sacks, 2 interceptions, 1 fumble recovered |
Roster