Trades
- April 14, 2010: Traded 2010 2nd round pick (43rd overall subsequently traded , Sergio Kindle) and 2011 2nd round pick (46th overall, Orlando Franklin) to Broncos for Brandon Marshall
- April 16, 2010: Traded Ted Ginn to 49ers for 2010 5th round pick (145th overall, Nolan Carroll)
- April 22, 2010: Traded 2010 1st round pick (12th overall, Ryan Mathews), 2010 4th round pick (110th overall, Darrell Stuckey) and 2010 6th round pick (173rd overall subsequently traded , Anthony Dixon) to Chargers for Tim Dobbins, 2010 1st round pick (28th overall, Jared Odrick), 2010 2nd round pick (40th overall, Koa Misi) and 2010 4th round pick (126th overall subsequently traded , Akwasi Owusu-Ansah)
- April 24, 2010: Traded 2010 4th round pick (126th overall, Akwasi Owusu-Ansah) and 2010 6th round pick (179th overall, Sam Young) to Cowboys for 2010 4th round pick (119th overall, A.J. Edds)
- April 24, 2010: Traded 2010 6th round pick (174th overall, Dennis Morris) and 2010 7th round pick (219th overall, Terrence Austin) to Redskins for 2010 5th round pick (163rd overall, Reshad Jones)
- May 25, 2010: Traded Justin Smiley to Jaguars for 2011 7th round pick (218th overall subsequently traded , Ryan Taylor)
- August 25, 2010: Traded Greg Camarillo to Vikings for Benny Sapp
- September 4, 2010: Traded a conditional 2010 pick (not conveyed) to Cowboys for Pat McQuistan
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