Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Kenny Pickett | 24 | Rook | 12 | 245 for 389, 2,404 yards, 7 td, 9 int, & 55 rushes for 237 yards and 3 td | |
| RB | Najee Harris | 24 | 1 | 17 | 272 rushes for 1,034 yards, 7 td, & 41 catches for 229 yards and 3 td | |
| WR | Diontae Johnson | 26 | 3 | 17 | 86 catches for 882 yards, 0 td, & 7 rushes for 25 yards and 0 td | |
| WR | George Pickens | 21 | Rook | 12 | 52 catches for 801 yards, 4 td, & 3 rushes for 24 yards and 1 td | |
| TE | Pat Freiermuth | 24 | 1 | 8 | 63 catches for 732 yards, 2 td | |
| TE | Zach Gentry | 26 | 3 | 13 | 19 catches for 132 yards, 0 td | |
| LT | Dan Moore | 24 | 1 | 17 | ||
| LG | Kevin Dotson | 26 | 2 | 17 | 1 fumble recovered | |
| C | Mason Cole | 26 | 4 | 17 | ||
| RG | James Daniels | 25 | 4 | 17 | ||
| RT | Chukwuma Okorafor | 25 | 4 | 17 | 1 fumble recovered | |
| Defensive Starters | ||||||
| LDE | Larry Ogunjobi | 28 | 5 | 16 | 1.5 sacks, 0 interceptions, 0 fumbles recovered | |
| DT | Cameron Heyward* | 33 | 11 | 17 | ||
| NT | Montravius Adams | 27 | 5 | 9 | ||
| LOLB | T.J. Watt* | 28 | 5 | 10 | 5.5 sacks, 2 interceptions, 0 fumbles recovered | |
| LILB | Devin Bush Jr. | 24 | 3 | 14 | ||
| RILB | Myles Jack | 27 | 6 | 13 | ||
| ROLB | Alex Highsmith | 25 | 2 | 17 | 14.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LCB | Levi Wallace | 27 | 4 | 9 | 0.0 sacks, 4 interceptions, 0 fumbles recovered | |
| RCB | Cameron Sutton | 27 | 5 | 15 | 0.0 sacks, 3 interceptions, 0 fumbles recovered | |
| SS | Terrell Edmunds | 25 | 4 | 15 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
| FS | Minkah Fitzpatrick*+ | 26 | 4 | 15 | 0.0 sacks, 6 interceptions, 0 fumbles recovered |
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