Trades
- April 4, 2022: Traded 2022 1st round pick (16th overall subsequently traded, Jahan Dotson), 2022 1st round pick (19th overall, Trevor Penning) and 2022 6th round pick (194th overall, Jordan Jackson) to Saints for 2022 1st round pick (18th overall subsequently traded, Treylon Burks), 2022 3rd round pick (101st overall subsequently traded, Jeremy Ruckert), 2022 7th round pick (237th overall subsequently traded, Chase Lucas), 2023 1st round pick (10th overall subsequently traded, Darnell Wright) and 2024 2nd round pick (50th overall subsequently traded, Mike Sainristil)
- April 28, 2022: Traded 2022 1st round pick (15th overall, Kenyon Green), 2022 4th round pick (124th overall subsequently traded, Cade York), 2022 5th round pick (162nd overall subsequently traded, Montrell Washington) and 2022 5th round pick (166th overall subsequently traded, Tycen Anderson) to Texans for 2022 1st round pick (13th overall, Jordan Davis)
- April 28, 2022: Traded 2022 1st round pick (18th overall, Treylon Burks) and 2022 3rd round pick (101st overall subsequently traded, Jeremy Ruckert) to Titans for A.J. Brown
- April 30, 2022: Traded 2022 5th round pick (154th overall, Snoop Conner) to Jaguars for 2022 6th round pick (188th overall subsequently traded, Malcolm Rodriguez) and 2022 6th round pick (198th overall, Grant Calcaterra)
- April 30, 2022: Traded 2022 6th round pick (188th overall, Malcolm Rodriguez) and 2022 7th round pick (237th overall, Chase Lucas) to Lions for 2022 6th round pick (181st overall, Kyron Johnson)
- August 15, 2022: Traded JJ Arcega-Whiteside to Seahawks for Ugo Amadi
- August 24, 2022: Traded Ugo Amadi and 2024 7th round pick (242nd overall, James Williams) to Titans for 2024 6th round pick (182nd overall subsequently traded, Jha'Quan Jackson)
- August 30, 2022: Traded 2023 5th round pick (165th overall subsequently traded, Terell Smith) and 2024 6th round pick (199th overall, Khristian Boyd) to Saints for C.J. Gardner-Johnson and a 2025 7th round pick
- August 31, 2022: Traded Jalen Reagor to Vikings for 2023 7th round pick (219th overall subsequently traded, Antoine Green) and 2024 5th round pick (146th overall subsequently traded, Jarvis Brownlee)
- October 26, 2022: Traded 2023 4th round pick (133rd overall, Tyler Scott) to Bears for Robert Quinn
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