| Offensive Starters | | | | | |
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| QB | Drew Brees* | 32 | 10 | 16 | 468 for 657, 5,476 yards, 46 td, 14 int, & 21 rushes for 86 yards and 1 td | |
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| RB | Pierre Thomas | 27 | 4 | 7 | 110 rushes for 562 yards, 5 td, & 50 catches for 425 yards and 1 td | |
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| FB | Jed Collins | 25 | Rook | 11 | 4 rushes for 4 yards, 2 td, & 11 catches for 50 yards and 2 td | |
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| WR | Devery Henderson | 29 | 7 | 13 | 32 catches for 503 yards, 2 td, & 1 rush for 9 yards and 0 td | |
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| WR | Robert Meachem | 27 | 3 | 8 | 40 catches for 620 yards, 6 td, & 4 rushes for 18 yards and 0 td | |
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| TE | Jimmy Graham* | 25 | 1 | 11 | 99 catches for 1,310 yards, 11 td | |
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| LT | Jermon Bushrod* | 27 | 4 | 16 | | |
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| LG | Carl Nicks*+ | 26 | 3 | 16 | | |
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| C | Brian De La Puente | 26 | Rook | 12 | | |
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| RG | Jahri Evans*+ | 28 | 5 | 16 | | |
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| RT | Zach Strief | 28 | 5 | 11 | | |
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| Defensive Starters | | | | | |
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| LDE | Cameron Jordan | 22 | Rook | 15 | 1.0 sacks, 0 interceptions, 1 fumble recovered | |
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| NT | Aubrayo Franklin | 31 | 8 | 9 | | |
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| RDE | Sedrick Ellis | 26 | 3 | 15 | 0.5 sacks, 0 interceptions, 0 fumbles recovered | |
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| LOLB | Will Smith | 30 | 7 | 14 | 6.5 sacks, 0 interceptions, 0 fumbles recovered | |
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| LILB | Jo-Lonn Dunbar | 26 | 3 | 14 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| RILB | Jonathan Vilma | 29 | 7 | 11 | 0.0 sacks, 0 interceptions, 3 fumbles recovered | |
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| ROLB | Scott Shanle | 32 | 8 | 15 | 1.0 sacks, 1 interception, 0 fumbles recovered | |
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| LCB | Jabari Greer | 29 | 7 | 16 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
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| RCB | Tracy Porter | 25 | 3 | 11 | 0.0 sacks, 1 interception, 1 fumble recovered | |
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| SS | Roman Harper | 29 | 5 | 16 | 7.5 sacks, 0 interceptions, 1 fumble recovered | |
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| FS | Malcolm Jenkins | 24 | 2 | 15 | 1.0 sacks, 0 interceptions, 1 fumble recovered | |
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Roster