Trades
- April 22, 2010: Traded 2010 1st round pick (30th overall, Jahvid Best) and 2010 4th round pick (128th overall, Jason Fox) to Lions for 2010 2nd round pick (34th overall, Chris Cook), 2010 4th round pick (100th overall, Everson Griffen) and 2010 7th round pick (214th overall, Mickey Shuler)
- April 23, 2010: Traded 2010 2nd round pick (62nd overall subsequently traded , Brandon Spikes) and 2010 3rd round pick (93rd overall subsequently traded , Tony Moeaki) to Texans for 2010 2nd round pick (51st overall, Toby Gerhart)
- August 25, 2010: Traded Benny Sapp to Dolphins for Greg Camarillo
- September 4, 2010: Traded Sage Rosenfels and Darius Reynaud to Giants for 2010 7th round pick
- October 5, 2010: Traded Jayme Mitchell to Browns for 2010 7th round pick
- October 6, 2010: Traded 2011 3rd round pick (74th overall, Ryan Mallett) to Patriots for Randy Moss and 2012 7th round pick (223rd overall subsequently traded , Travis Lewis)
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