Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Matt Cassel | 27 | 4 | 15 | 271 for 493, 2,924 yards, 16 td, 16 int, & 50 rushes for 189 yards and 0 td | |
| RB | Jamaal Charles | 23 | 1 | 10 | 190 rushes for 1,120 yards, 7 td, & 40 catches for 297 yards and 1 td | |
| FB | Mike Cox | 24 | 1 | 10 | 3 rushes for 5 yards, 1 td, & 10 catches for 79 yards and 0 td | |
| WR | Dwayne Bowe | 25 | 2 | 9 | 47 catches for 589 yards, 4 td | |
| WR | Chris Chambers | 31 | 8 | 9 | 36 catches for 608 yards, 4 td | |
| TE | Leonard Pope | 26 | 3 | 8 | 20 catches for 174 yards, 1 td | |
| LT | Branden Albert | 25 | 1 | 14 | 1 fumble recovered | |
| LG | Brian Waters | 32 | 9 | 15 | 3 fumbles recovered | |
| C | Rudy Niswanger | 27 | 3 | 16 | ||
| RG | Wade Smith | 28 | 6 | 9 | ||
| RT | Ryan O'Callaghan | 26 | 3 | 12 | 1 fumble recovered | |
| Defensive Starters | ||||||
| LDE | Tyson Jackson | 23 | Rook | 14 | ||
| NT | Ron Edwards | 30 | 8 | 14 | 0.0 sacks, 0 interceptions, 1 fumble recovered | |
| RDE | Glenn Dorsey | 24 | 1 | 14 | 1.0 sacks, 0 interceptions, 3 fumbles recovered | |
| LOLB | Mike Vrabel | 34 | 12 | 14 | 2.0 sacks, 0 interceptions, 1 fumble recovered | |
| LILB | Demorrio Williams | 29 | 5 | 13 | ||
| RILB | Corey Mays | 26 | 3 | 13 | ||
| ROLB | Tamba Hali | 26 | 3 | 16 | 8.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LCB | Brandon Flowers | 23 | 1 | 15 | 0.0 sacks, 5 interceptions, 2 fumbles recovered | |
| RCB | Brandon Carr | 23 | 1 | 16 | 0.0 sacks, 1 interception, 2 fumbles recovered | |
| SS | Mike Brown | 31 | 9 | 16 | 2.0 sacks, 3 interceptions, 1 fumble recovered | |
| FS | Jon McGraw | 30 | 7 | 9 | 1.0 sacks, 1 interception, 1 fumble recovered |
Roster