| Offensive Starters | | | | | |
|---|
| QB | Matthew Stafford | 25 | 4 | 16 | 371 for 634, 4,650 yards, 29 td, 19 int, & 37 rushes for 69 yards and 2 td | |
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| RB | Reggie Bush | 28 | 7 | 14 | 223 rushes for 1,006 yards, 4 td, & 54 catches for 506 yards and 3 td | |
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| WR | Nate Burleson | 32 | 10 | 8 | 39 catches for 461 yards, 1 td, & 2 rushes for -8 yards and 0 td | |
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| WR | Kris Durham | 25 | 2 | 13 | 38 catches for 490 yards, 2 td | |
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| WR | Calvin Johnson*+ | 28 | 6 | 14 | 84 catches for 1,492 yards, 12 td | |
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| TE | Brandon Pettigrew | 28 | 4 | 14 | 41 catches for 416 yards, 2 td | |
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| LT | Riley Reiff | 25 | 1 | 16 | 1 fumble recovered | |
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| LG | Rob Sims | 30 | 7 | 16 | | |
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| C | Dominic Raiola | 35 | 12 | 16 | | |
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| RG | Larry Warford | 22 | Rook | 16 | | |
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| RT | LaAdrian Waddle | 22 | Rook | 8 | | |
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| Defensive Starters | | | | | |
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| LDE | Ezekiel Ansah | 24 | Rook | 12 | 8.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| LDT | Nick Fairley | 25 | 2 | 15 | 6.0 sacks, 0 interceptions, 2 fumbles recovered | |
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| RDT | Ndamukong Suh*+ | 26 | 3 | 16 | 5.5 sacks, 0 interceptions, 0 fumbles recovered | |
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| RDE | Willie Young | 28 | 3 | 15 | 3.0 sacks, 0 interceptions, 2 fumbles recovered | |
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| LLB | Ashlee Palmer | 27 | 4 | 10 | 0.0 sacks, 0 interceptions, 1 fumble recovered | |
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| MLB | Stephen Tulloch | 28 | 7 | 16 | 3.5 sacks, 1 interception, 0 fumbles recovered | |
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| RLB | DeAndre Levy | 26 | 4 | 16 | 0.0 sacks, 6 interceptions, 0 fumbles recovered | |
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| LCB | Chris Houston | 29 | 6 | 12 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
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| RCB | Rashean Mathis | 33 | 10 | 13 | | |
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| SS | Glover Quin | 27 | 4 | 16 | 2.0 sacks, 3 interceptions, 1 fumble recovered | |
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| FS | Louis Delmas | 26 | 4 | 15 | 2.0 sacks, 3 interceptions, 0 fumbles recovered | |
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Roster