Trades
- March 5, 2010: Traded 2010 5th round pick (146th overall subsequently traded , Cam Thomas) and 2010 7th round pick (214th overall subsequently traded , Mickey Shuler) to Browns for Corey Williams and 2010 7th round pick
- March 8, 2010: Traded 2010 6th round pick (171st overall, Shann Schillinger) and 2011 7th round pick (210th overall, Andrew Jackson) to Falcons for Chris Houston and 2010 5th round pick (149th overall subsequently traded , Hall Davis)
- March 15, 2010: Traded 2010 7th round pick to 49ers for Shaun Hill
- April 5, 2010: Traded Robert Henderson and 2010 5th round pick (133rd overall, Kam Chancellor) to Seahawks for Rob Sims and 2010 7th round pick (213th overall, Willie Young)
- April 19, 2010: Lions sent Ernie Sims to Eagles. Broncos sent Tony Scheffler and 2010 7th round pick (220th overall subsequently traded , Jamar Chaney) to Lions. Eagles sent 2010 5th round pick (137th overall, Perrish Cox) to Broncos.
- April 22, 2010: Traded 2010 2nd round pick (34th overall, Chris Cook), 2010 4th round pick (100th overall, Everson Griffen) and 2010 7th round pick (214th overall, Mickey Shuler) to Vikings for 2010 1st round pick (30th overall, Jahvid Best) and 2010 4th round pick (128th overall, Jason Fox)
- April 24, 2010: Traded 2010 7th round pick (220th overall, Jamar Chaney) to Eagles for 2011 6th round pick (186th overall subsequently traded , D.J. Smith)
- August 18, 2010: Traded 2011 6th round pick (173rd overall, Byron Maxwell) to Seahawks for Lawrence Jackson
- August 31, 2010: Traded Tyler Polumbus to Seahawks for 2010 7th round pick
- September 4, 2010: Traded Dan Gronkowski and 2011 6th round pick (186th overall subsequently traded , D.J. Smith) to Broncos for Alphonso Smith and 2011 7th round pick (pick forfeited due to tampering)
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