- March 5, 2010: Traded Corey Williams and 2010 7th round pick to Lions for 2010 5th round pick (146th overall subsequently traded, Cam Thomas) and 2010 7th round pick (214th overall subsequently traded, Mickey Shuler)
- March 9, 2010: Traded 2011 7th round pick (209th overall subsequently traded, Johnny Culbreath) to Seahawks for Seneca Wallace
- March 15, 2010: Traded Brady Quinn to Broncos for Peyton Hillis, 2011 6th round pick (168th overall subsequently traded, Demarcus Love) and 2012 5th round pick (160th overall, Ryan Miller)
- March 15, 2010: Traded Kamerion Wimbley to Raiders for 2010 3rd round pick (85th overall, Colt McCoy)
- April 2, 2010: Traded Alex Hall, 2010 4th round pick (105th overall, Trevard Lindley) and 2010 5th round pick (137th overall subsequently traded, Perrish Cox) to Eagles for Sheldon Brown and Chris Gocong
- April 23, 2010: Traded 2010 3rd round pick (71st overall subsequently traded, Morgan Burnett), 2010 5th round pick (134th overall, Ricky Sapp) and 2010 5th round pick (146th overall subsequently traded, Cam Thomas) to Eagles for 2010 2nd round pick (59th overall, Montario Hardesty)
- October 5, 2010: Traded 2010 7th round pick to Vikings for Jayme Mitchell
- October 18, 2010: Traded Jerome Harrison to Eagles for Mike Bell
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