Trades
- March 5, 2010: Traded Corey Williams and 2010 7th round pick to Lions for 2010 5th round pick (146th overall subsequently traded , Cam Thomas) and 2010 7th round pick (214th overall subsequently traded , Mickey Shuler)
- March 9, 2010: Traded 2011 7th round pick (209th overall subsequently traded , Johnny Culbreath) to Seahawks for Seneca Wallace
- March 15, 2010: Traded Brady Quinn to Broncos for Peyton Hillis, 2011 6th round pick (168th overall subsequently traded , Demarcus Love) and 2012 5th round pick (160th overall, Ryan Miller)
- March 15, 2010: Traded Kamerion Wimbley to Raiders for 2010 3rd round pick (85th overall, Colt McCoy)
- April 2, 2010: Traded Alex Hall, 2010 4th round pick (105th overall, Trevard Lindley) and 2010 5th round pick (137th overall subsequently traded , Perrish Cox) to Eagles for Sheldon Brown and Chris Gocong
- April 23, 2010: Traded 2010 3rd round pick (71st overall subsequently traded , Morgan Burnett), 2010 5th round pick (134th overall, Ricky Sapp) and 2010 5th round pick (146th overall subsequently traded , Cam Thomas) to Eagles for 2010 2nd round pick (59th overall, Montario Hardesty)
- October 5, 2010: Traded 2010 7th round pick to Vikings for Jayme Mitchell
- October 18, 2010: Traded Jerome Harrison to Eagles for Mike Bell
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