Trades
- March 10, 2022: Traded Khalil Mack to Chargers for 2022 2nd round pick (48th overall, Jaquan Brisker) and 2023 6th round pick (200th overall subsequently traded, Scott Matlock)
- April 30, 2022: Traded 2022 5th round pick (148th overall, Khalil Shakir) to Bills for 2022 5th round pick (168th overall, Braxton Jones) and 2022 6th round pick (203rd overall, Trestan Ebner)
- April 30, 2022: Traded 2022 5th round pick (150th overall, Thomas Booker) to Texans for 2022 5th round pick (166th overall subsequently traded, Tycen Anderson) and 2022 6th round pick (207th overall, Doug Kramer)
- April 30, 2022: Traded 2022 5th round pick (166th overall, Tycen Anderson) to Bengals for 2022 5th round pick (174th overall, Dominique Robinson) and 2022 7th round pick (226th overall, Ja'Tyre Carter)
- April 30, 2022: Traded 2023 6th round pick (200th overall, Scott Matlock) to Chargers for 2022 7th round pick (254th overall, Elijah Hicks) and 2022 7th round pick (255th overall, Trenton Gill)
- July 12, 2022: Traded 2024 7th round pick (231st overall, Jaheim Bell) to Patriots for N'Keal Harry
- October 26, 2022: Traded Robert Quinn to Eagles for 2023 4th round pick (133rd overall, Tyler Scott)
- October 31, 2022: Traded Roquan Smith to Ravens for 2023 2nd round pick (53rd overall, Gervon Dexter), 2023 5th round pick (148th overall, Noah Sewell) and A.J. Klein
- November 1, 2022: Traded 2023 2nd round pick (32nd overall, Joey Porter) to Steelers for Chase Claypool
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