1981 Week 3
| Sep 17, 1981 | ||
| Philadelphia Eagles | 20 | Final |
| Buffalo Bills | 14 | |
| PassYds | Jaworski-PHI | 240 |
| RushYds | Montgomery-PHI | 125 |
| RecYds | Lewis-BUF | 108 |
| Sep 20, 1981 | ||
| San Francisco 49ers | 17 | Final |
| Atlanta Falcons | 34 | |
| PassYds | Montana-SFO | 274 |
| RushYds | Andrews-ATL | 85 |
| RecYds | Jenkins-ATL | 82 |
| Sep 20, 1981 | ||
| Cleveland Browns | 20 | Final |
| Cincinnati Bengals | 17 | |
| PassYds | Sipe-CLE | 259 |
| RushYds | Miller-CLE | 96 |
| RecYds | Curtis-CIN | 79 |
| Sep 20, 1981 | ||
| Washington Redskins | 30 | Final |
| St. Louis Cardinals | 40 | |
| PassYds | Theismann-WAS | 388 |
| RushYds | Jackson-WAS | 104 |
| RecYds | Monk-WAS | 128 |
| Sep 20, 1981 | ||
| Detroit Lions | 24 | Final |
| Minnesota Vikings | 26 | |
| PassYds | Kramer-MIN | 333 |
| RushYds | Sims-DET | 112 |
| RecYds | Brown-MIN | 115 |
| Sep 20, 1981 | ||
| Miami Dolphins | 16 | Final |
| Houston Oilers | 10 | |
| PassYds | Stabler-HOU | 178 |
| RushYds | Campbell-HOU | 78 |
| RecYds | Burrough-HOU | 76 |
| Sep 20, 1981 | ||
| New York Jets | 10 | Final |
| Pittsburgh Steelers | 38 | |
| PassYds | Bradshaw-PIT | 225 |
| RushYds | Davis-PIT | 100 |
| RecYds | Stallworth-PIT | 134 |
| Sep 20, 1981 | ||
| Tampa Bay Buccaneers | 17 | Final |
| Chicago Bears | 28 | |
| PassYds | Williams-TAM | 324 |
| RushYds | Eckwood-TAM | 114 |
| RecYds | Giles-TAM | 109 |
| Sep 20, 1981 | ||
| San Diego Chargers | 42 | Final |
| Kansas City Chiefs | 31 | |
| PassYds | Kenney-KAN | 303 |
| RushYds | Muncie-SDG | 93 |
| RecYds | Smith-KAN | 140 |
| Sep 20, 1981 | ||
| Baltimore Colts | 10 | Final |
| Denver Broncos | 28 | |
| PassYds | Morton-DEN | 291 |
| RushYds | Dickey-BAL | 115 |
| RecYds | Watson-DEN | 143 |
| Sep 20, 1981 | ||
| New Orleans Saints | 7 | Final |
| New York Giants | 20 | |
| PassYds | Simms-NYG | 324 |
| RushYds | Rogers-NOR | 75 |
| RecYds | Perkins-NYG | 118 |
| Sep 20, 1981 | ||
| Seattle Seahawks | 10 | Final |
| Oakland Raiders | 20 | |
| PassYds | Zorn-SEA | 327 |
| RushYds | Jensen-OAK | 84 |
| RecYds | McCullum-SEA | 122 |
| Sep 20, 1981 | ||
| Green Bay Packers | 23 | Final |
| Los Angeles Rams | 35 | |
| PassYds | Dickey-GNB | 125 |
| RushYds | Tyler-RAM | 108 |
| RecYds | Lofton-GNB | 73 |
| Sep 21, 1981 | ||
| Dallas Cowboys | 35 | Final |
| New England Patriots | 21 | |
| PassYds | Cavanaugh-NWE | 235 |
| RushYds | Dorsett-DAL | 162 |
| RecYds | Hasselbeck-NWE | 93 |
1981 Week Summaries