1981 Week 12
| Nov 22, 1981 | ||
| New England Patriots | 17 | Final |
| Buffalo Bills | 20 | |
| PassYds | Ferguson-BUF | 258 |
| RushYds | Leaks-BUF | 92 |
| RecYds | Morgan-NWE | 141 |
| Nov 22, 1981 | ||
| Detroit Lions | 23 | Final |
| Chicago Bears | 7 | |
| PassYds | Hipple-DET | 145 |
| RushYds | Sims-DET | 117 |
| RecYds | Scott-DET | 68 |
| Nov 22, 1981 | ||
| Denver Broncos | 21 | Final |
| Cincinnati Bengals | 38 | |
| PassYds | Anderson-CIN | 396 |
| RushYds | Johnson-CIN | 99 |
| RecYds | Ross-CIN | 123 |
| Nov 22, 1981 | ||
| Pittsburgh Steelers | 32 | Final |
| Cleveland Browns | 10 | |
| PassYds | Sipe-CLE | 227 |
| RushYds | Pruitt-CLE | 96 |
| RecYds | Feacher-CLE | 79 |
| Nov 22, 1981 | ||
| New Orleans Saints | 27 | Final |
| Houston Oilers | 24 | |
| PassYds | Stabler-HOU | 190 |
| RushYds | Rogers-NOR | 142 |
| RecYds | Holston-HOU | 84 |
| Nov 22, 1981 | ||
| New York Giants | 20 | Final |
| Philadelphia Eagles | 10 | |
| PassYds | Jaworski-PHI | 187 |
| RushYds | Carpenter-NYG | 111 |
| RecYds | Campfield-PHI | 69 |
| Nov 22, 1981 | ||
| Green Bay Packers | 3 | Final |
| Tampa Bay Buccaneers | 37 | |
| PassYds | Campbell-GNB | 168 |
| RushYds | Owens-TAM | 112 |
| RecYds | Lofton-GNB | 102 |
| Nov 22, 1981 | ||
| St. Louis Cardinals | 35 | Final |
| Baltimore Colts | 24 | |
| PassYds | Jones-BAL | 230 |
| RushYds | Anderson-STL | 130 |
| RecYds | Tilley-STL | 158 |
| Nov 22, 1981 | ||
| Seattle Seahawks | 13 | Final |
| Kansas City Chiefs | 40 | |
| PassYds | Zorn-SEA | 258 |
| RushYds | Hadnot-KAN | 106 |
| RecYds | Smith-KAN | 70 |
| Nov 22, 1981 | ||
| Washington Redskins | 10 | Final |
| Dallas Cowboys | 24 | |
| PassYds | White-DAL | 222 |
| RushYds | Dorsett-DAL | 115 |
| RecYds | Pearson-DAL | 111 |
| Nov 22, 1981 | ||
| Miami Dolphins | 15 | Final |
| New York Jets | 16 | |
| PassYds | Todd-NYJ | 203 |
| RushYds | McNeil-NYJ | 75 |
| RecYds | Barkum-NYJ | 43 |
| Nov 22, 1981 | ||
| San Diego Chargers | 55 | Final |
| Oakland Raiders | 21 | |
| PassYds | Fouts-SDG | 296 |
| RushYds | Brooks-SDG | 97 |
| RecYds | Winslow-SDG | 144 |
| Nov 22, 1981 | ||
| San Francisco 49ers | 33 | Final |
| Los Angeles Rams | 31 | |
| PassYds | Montana-SFO | 283 |
| RushYds | Tyler-RAM | 97 |
| RecYds | Solomon-SFO | 124 |
| Nov 23, 1981 | ||
| Minnesota Vikings | 30 | Final |
| Atlanta Falcons | 31 | |
| PassYds | Kramer-MIN | 330 |
| RushYds | Brown-MIN | 108 |
| RecYds | Rashad-MIN | 151 |
1981 Week Summaries