| Offensive Starters | | | | | |
|---|
| QB | Matt Schaub | 27 | 4 | 11 | 251 for 380, 3,043 yards, 15 td, 10 int, & 31 rushes for 68 yards and 2 td | |
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| RB | Steve Slaton | 22 | Rook | 15 | 268 rushes for 1,282 yards, 9 td, & 50 catches for 377 yards and 1 td | |
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| FB | Vonta Leach | 27 | 4 | 12 | 1 rush for 1 yards, 1 td, & 12 catches for 103 yards and 0 td | |
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| WR | Andre Johnson*+ | 27 | 5 | 16 | 115 catches for 1,575 yards, 8 td | |
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| WR | Kevin Walter | 27 | 5 | 16 | 60 catches for 899 yards, 8 td, & 3 rushes for 23 yards and 0 td | |
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| TE | Owen Daniels* | 26 | 2 | 16 | 70 catches for 862 yards, 2 td | |
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| LT | Duane Brown | 23 | Rook | 16 | 2 fumbles recovered | |
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| LG | Chester Pitts | 29 | 6 | 16 | 1 fumble recovered | |
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| C | Chris Myers | 27 | 3 | 16 | | |
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| RG | Mike Brisiel | 25 | 1 | 16 | | |
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| RT | Eric Winston | 25 | 2 | 16 | | |
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| Defensive Starters | | | | | |
|---|
| LDE | Anthony Weaver | 28 | 6 | 16 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
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| LDT | Travis Johnson | 26 | 3 | 14 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| RDT | Amobi Okoye | 21 | 1 | 12 | 1.0 sacks, 0 interceptions, 1 fumble recovered | |
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| RDE | Mario Williams* | 23 | 2 | 16 | 12.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| LLB | Zach Diles | 23 | 1 | 8 | 1.0 sacks, 1 interception, 0 fumbles recovered | |
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| MLB | DeMeco Ryans | 24 | 2 | 16 | 1.0 sacks, 0 interceptions, 3 fumbles recovered | |
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| RLB | Morlon Greenwood | 30 | 7 | 10 | | |
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| LCB | Fred Bennett | 25 | 1 | 6 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
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| RCB | Jacques Reeves | 26 | 4 | 16 | 0.0 sacks, 4 interceptions, 1 fumble recovered | |
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| SS | Nick Ferguson | 34 | 8 | 9 | 0.0 sacks, 0 interceptions, 1 fumble recovered | |
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| FS | Eugene Wilson | 28 | 5 | 10 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
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Roster