Starters
- *ProBowl, +1st-tm All-Pro
| Pos | Player | Age | Yrs | GS | Summary of Player Stats | Drafted (tm/rnd/yr) |
|---|---|---|---|---|---|---|
| Offensive Starters | ||||||
| QB | Drew Lock | 24 | 1 | 13 | 254 for 443, 2,933 yards, 16 td, 15 int, & 44 rushes for 160 yards and 3 td | |
| RB | Melvin Gordon | 27 | 5 | 10 | 215 rushes for 986 yards, 9 td, & 32 catches for 158 yards and 1 td | |
| WR | Jerry Jeudy | 21 | Rook | 14 | 52 catches for 856 yards, 3 td | |
| WR | Tim Patrick | 27 | 2 | 15 | 51 catches for 742 yards, 6 td | |
| TE | Noah Fant | 23 | 1 | 14 | 62 catches for 673 yards, 3 td | |
| TE | Nick Vannett | 27 | 4 | 11 | 14 catches for 95 yards, 1 td | |
| LT | Garett Bolles | 28 | 3 | 15 | ||
| LG | Dalton Risner | 25 | 1 | 16 | ||
| C | Lloyd Cushenberry III | 23 | Rook | 16 | 1 fumble recovered | |
| RG | Graham Glasgow | 28 | 4 | 13 | ||
| RT | Demar Dotson | 35 | 11 | 8 | ||
| Defensive Starters | ||||||
| LDE | Shelby Harris | 29 | 6 | 11 | 2.5 sacks, 0 interceptions, 0 fumbles recovered | |
| NT | DeShawn Williams | 28 | 4 | 11 | 2.0 sacks, 1 interception, 0 fumbles recovered | |
| RDE | Dre'Mont Jones | 23 | 1 | 8 | 6.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LOLB | Malik Reed | 24 | 1 | 13 | 8.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LILB | Alexander Johnson | 29 | 2 | 16 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
| RILB | Josey Jewell | 26 | 2 | 16 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
| ROLB | Bradley Chubb* | 24 | 2 | 14 | 7.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LCB | A.J. Bouye | 29 | 7 | 7 | ||
| RCB | Bryce Callahan | 29 | 5 | 10 | 0.0 sacks, 2 interceptions, 1 fumble recovered | |
| SS | Kareem Jackson | 32 | 10 | 16 | 0.0 sacks, 1 interception, 2 fumbles recovered | |
| FS | Justin Simmons* | 27 | 4 | 16 | 0.0 sacks, 5 interceptions, 1 fumble recovered |
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