| Offensive Starters | | | | | |
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| QB | Peyton Manning * | 34 | 12 | 16 | 450 for 679, 4,700 yards, 33 td, 17 int, & 18 rushes for 18 yards and 0 td | Indianapolis Colts / 1st / 1st pick / 1998 |
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| RB | Donald Brown | 23 | 1 | 8 | 129 rushes for 497 yards, 2 td, & 20 catches for 205 yards and 0 td | Indianapolis Colts / 1st / 27th pick / 2009 |
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| WR | Pierre Garcon | 24 | 2 | 14 | 67 catches for 784 yards, 6 td, & 2 rushes for 6 yards and 0 td | Indianapolis Colts / 6th / 205th pick / 2008 |
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| WR | Reggie Wayne*+ | 32 | 9 | 16 | 111 catches for 1,355 yards, 6 td | Indianapolis Colts / 1st / 30th pick / 2001 |
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| TE | Brody Eldridge | 23 | Rook | 8 | 5 catches for 39 yards, 0 td | Indianapolis Colts / 5th / 162nd pick / 2010 |
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| TE | Jacob Tamme | 25 | 2 | 8 | 67 catches for 631 yards, 4 td | Indianapolis Colts / 4th / 127th pick / 2008 |
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| LT | Charlie Johnson | 26 | 4 | 15 | | Indianapolis Colts / 6th / 199th pick / 2006 |
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| LG | Kyle DeVan | 25 | 1 | 12 | | |
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| C | Jeff Saturday * | 35 | 11 | 16 | 1 fumble recovered | |
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| RG | Mike Pollak | 25 | 2 | 13 | | Indianapolis Colts / 2nd / 59th pick / 2008 |
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| RT | Ryan Diem | 31 | 9 | 16 | | Indianapolis Colts / 4th / 118th pick / 2001 |
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| Defensive Starters | | | | | |
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| LDE | Robert Mathis* | 29 | 7 | 16 | 11.0 sacks, 0 interceptions, 1 fumble recovered | Indianapolis Colts / 5th / 138th pick / 2003 |
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| LDT | Fili Moala | 25 | 1 | 16 | 0.0 sacks, 0 interceptions, 1 fumble recovered | Indianapolis Colts / 2nd / 56th pick / 2009 |
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| RDT | Daniel Muir | 27 | 3 | 14 | | |
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| RDE | Dwight Freeney* | 30 | 8 | 16 | 10.0 sacks, 0 interceptions, 0 fumbles recovered | Indianapolis Colts / 1st / 11th pick / 2002 |
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| LLB | Pat Angerer | 23 | Rook | 11 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | Indianapolis Colts / 2nd / 63rd pick / 2010 |
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| MLB | Gary Brackett | 30 | 7 | 12 | 0.5 sacks, 0 interceptions, 0 fumbles recovered | |
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| RLB | Kavell Conner | 23 | Rook | 9 | 0.0 sacks, 0 interceptions, 1 fumble recovered | Indianapolis Colts / 7th / 240th pick / 2010 |
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| LCB | Kelvin Hayden | 27 | 5 | 11 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | Indianapolis Colts / 2nd / 60th pick / 2005 |
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| RCB | Jerraud Powers | 23 | 1 | 10 | 0.0 sacks, 2 interceptions, 1 fumble recovered | Indianapolis Colts / 3rd / 92nd pick / 2009 |
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| SS | Aaron Francisco | 27 | 5 | 12 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
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| FS | Antoine Bethea | 26 | 4 | 16 | 0.5 sacks, 1 interception, 0 fumbles recovered | Indianapolis Colts / 6th / 207th pick / 2006 |
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